翻訳と辞書 Words near each other ・ 5-HT1D receptor ・ 5-HT1D receptor agonist ・ 5-HT1E receptor ・ 5-HT1F receptor ・ 5-HT2 receptor ・ 5-HT2A receptor ・ 5-HT2B receptor ・ 5-HT2C receptor ・ 5-HT2c receptor agonist ・ 5-HT3 antagonist ・ 5-HT3 receptor ・ 5-HT4 receptor ・ 5-HT5A receptor ・ 5-HT5B receptor ・ 5-HT6 receptor ・ 5-HT7 receptor ・ 5-HTTLPR ・ 5-Hydroxy-2(5H)-furanone ・ 5-Hydroxycytosine ・ 5-Hydroxyeicosanoid dehydrogenase ・ 5-Hydroxyferulic acid ・ 5-hydroxyfuranocoumarin 5-O-methyltransferase ・ 5-Hydroxyhydantoin ・ 5-Hydroxyicosatetraenoic acid ・ 5-Hydroxyindoleacetic acid ・ 5-Hydroxyisourate ・ 5-Hydroxymaltol ・ 5-Hydroxymethylcytosine ・ 5-hydroxypentanoate CoA-transferase ・ 5-Hydroxytryptophan Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク 5-HT7 receptor ： ウィキペディア英語版 5-HT7 receptor The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) The 5-HT7 receptor is coupled to Gs (stimulates the production of the intracellular signaling molecule cAMP) and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels.〔 This receptor has been a drug development target for the treatment of several clinical disorders. The 5-HT7 receptor is encoded by the ''HTR7'' gene, which in humans is transcribed into 3 different splice variants. == Function == When the 5-HT7 receptor is activated by serotonin, it sets off a cascade of events starting with release of the stimulatory G protein Gs from the GPCR complex. Gs in turn activates adenylate cyclase which increases intracellular levels of the second messenger cAMP. The 5-HT7 receptor plays a role in smooth muscle relaxation within the vasculature and in the gastrointestinal tract.〔 The highest 5-HT7 receptor densities are in the thalamus and hypothalamus, and it is present at higher densities also in the hippocampus and cortex. The 5-HT7 receptor is involved in thermoregulation, circadian rhythm, learning and memory, and sleep. It is also speculated that this receptor may be involved in mood regulation, suggesting that it may be a useful target in the treatment of depression. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「5-HT7 receptor」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.